Table 2. Association between genetic polymorphisms in folate metabolism genes and PCa risk in Han Chinese men.
| Gene | SNP | Type | Genotype | Cases (n = 1817) | Controls (n = 2026) | PHWE | Crude OR (95% CI) | P | Adjusted OR (95% CI)c | Pa |
|---|---|---|---|---|---|---|---|---|---|---|
| MTHFR | rs1801133 | Nonsynonymous (exon 4) | CC | 654 (36.0) | 599 (29.6) | 0.580 | 1.00 | 1 × 10−5 | 1.00 | 3 × 10−4 |
| CT | 876 (48.2) | 1022 (50.4) | 0.79 (0.68–0.91) | 0.78 (0.67–0.92) | ||||||
| TT | 287 (15.8) | 405 (20.0) | 0.65 (0.54–0.78) | 0.68 (0.55–0.83) | ||||||
| Dominant model | 0.75 (0.65–0.85) | 2 × 10−5 | 0.75 (0.65–0.87) | 2 × 10−4 | ||||||
| Recessive model | 0.75 (0.64–0.89) | 7 × 10−4 | 0.78 (0.65–0.94) | 0.008 | ||||||
| Additive model | 0.80 (0.73–0.88) | 6 × 10−5 | 0.82 (0.74–0.90) | 1 × 10−4 | ||||||
| rs1801131 | Nonsynonymous (exon 7) | AA | 1192 (65.6) | 1355 (66.9) | 0.220 | 1.00 | 0.690 | 1.00 | 0.680 | |
| AC | 569 (31.3) | 609 (30.1) | 1.06 (0.92–1.22) | 1.07 (0.92–1.24) | ||||||
| CC | 56 (3.1) | 62 (3.1) | 1.03 (0.71–1.49) | 1.06 (0.72–1.58) | ||||||
| Dominant model | 1.06 (0.93–1.21) | 0.400 | 1.07 (0.92–1.24) | 0.380 | ||||||
| Recessive model | 1.01 (0.70–1.45) | 0.970 | 1.04 (0.70–1.55) | 0.830 | ||||||
| Additive model | 1.05 (0.93–1.17) | 0.460 | 1.06 (0.93–1.20) | 0.410 | ||||||
PCa, prostate cancer; OR, odds ratio; 95%CI, 95% confidence interval.
HWEP value for the Hardy–Weinberg equilibrium test in controls subjects.
aAdjusted for age, BMI, hypertension, diabetes mellitus and cardiovascular disease in multivariant logistic regression models.