Table 1.

Evidence supporting a role for N/OFQ in obestity

Preparation	Findings	Reference
N/OFQ into brain of sated mice and rats	Stimulation of feeding	Olszewski and Levine, 2004
N/OFQ into the CNS of fat-prefering rats	Stimulation of feeding	Olszewski et al., 2002
N/OFQ into the CNS of rats	Stimulation of c-fos expression in the NTS, PVN, central amygdala, lateral septum and habenular nuclei	Olszewski et al., 2000
N/OFQ and N/OFQ agoinst Ro 64-6198	Inhibitition of anorectic effects of CRF N/OFQ	Ciccocioppo et al., 2002; 2004
Chronic central administration of N/OFQ	Increased body weight by inducing hyperphagia and by decreasing energy expenditure	Matsushita et al., 2009
N/OFQ antagonist SB612111	Inhibition of fasting-induced feeding; effect absent in NOP receptor −/− mice	Figure 2
Fasting in rats	Reduces N/OFQ and ORL1/NOP gene expression within the CNS	Rodi et al., 2002; Przydzial et al., 2009

DIO: diet-induced obese

NTS: nucleus of the solitary tract

PVN: paraventricular nucleus