. Author manuscript; available in PMC: 2017 Oct 1.

Published in final edited form as: J Neurol Neurosurg Psychiatry. 2016 Apr 13;87(10):1106–1111. doi: 10.1136/jnnp-2015-312848

Table 4.

Single factor associations with ICD incidence in the multivariable non-linear model, patients taking DA only

Factor	Multivariable p Value
(Intercept)	0.578
OPRK1: rs702764: TC genotype	0.038
OPRK1: rs702764: CC genotype	0.997
HTR2A: rs6313: GA genotype	0.008
HTR2A: rs6313: AA genotype	0.456
DDC: rs383709: −/AGAG genotype	0.01
DDC: rs3837091: −/− genotype	0.043
DDC: rs1451375: CA genotype	0.122
DDC: rs1451375: AA genotype	0.037
ADRA2C: rs76337672: GC genotype	0.705
ADRA2C: rs76337672: CC genotype	0.995
DRD2: rs1800497: GA genotype	0.655
DRD2: rs1800497: AA genotype	0.993
Age	0.071
Sex	0.014
Dopamine agonist use	0.001

Sets of variables were determined using stepwise regression. p Values for each variable were adjusted for the other covariates. Subgroup analysis was performed on 149 patients who either were on DA treatment or did not receive DRT during follow-up.

DA, dopamine agonist; DRT, dopamine replacement therapy; ICD, impulse control disorders.