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EC50 values calculated in Healthy donors-peripheral blood mononuclear cells (HD-PBMCs) and in both lymphoid and myeloid cell lines after 4c compound treatment.
| Cells | EC50 [μM] |
|||
|---|---|---|---|---|
| 24 h | 48 h | 72 h | ||
| HD-PBMCs | >15 | >15 | >15 | |
| Lymphoid Neoplasms | Jurkat | 4.6 | 4 | 3.8 |
| SKMM1 | 7.7 | 8.11 | 10.8 | |
| Derl-2 | 7.5 | 5.9 | 6.2 | |
| Derl-7 | 12.3 | 4.7 | 4.7 | |
| BV-173 | >15 | 6.6 | 7.15 | |
| NALM-6 | >15 | >15 | >15 | |
| Myeloid Neoplasms | Jurl-MK1 | >15 | 2.5 | 2.4 |
| NB-4 | >15 | 7.2 | 5.9 | |
| HL-60 | >15 | >15 | >15 | |
| OCI-AML3 | >15 | >15 | >15 | |
| Kasumi-1 | >15 | 15 | 15 | |
