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. Author manuscript; available in PMC: 2016 Nov 7.
Published in final edited form as: DNA Repair (Amst). 2015 Aug 12;34:39–51. doi: 10.1016/j.dnarep.2015.08.001

Figure 1.

Figure 1

MUTYH missense and nonsense mutations located in functional domains of the protein. Shown is the α3 transcript of the human MUTYH gene which encodes a 535 amino acid protein. The various binding partners of MUTYH are represented as shapes: replication protein A (RPA), red pentagon; mutS 6 homologue (MSH6), purple trapezoid; Hus1, yellow oval; AP endonuclease 1 (APE1), green pac man symbol; and proliferating cell nuclear antigen (PCNA), brown diamond.