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. Author manuscript; available in PMC: 2016 Nov 7.
Published in final edited form as: DNA Repair (Amst). 2015 Aug 12;34:39–51. doi: 10.1016/j.dnarep.2015.08.001

Figure 7.

Figure 7

Impact of replacement of Pro 281 in FCL motif of MUTYH. (A) A view of the FCL motif in the structure of MUTYH (PDB code 3N5N) is shown with [4Fe-4S]2+ cluster in orange/gold spheres, the FCL motif in green with side chains shown, and Pro 281 colored pink. (B) In the same orientation, Pro 281 is replaced with a Leu in silico. The snug fit and potential steric clashes suggest that this replacement would significantly alter the conformation of the FCL motif and disrupt ability to bind properly to the DNA substrate.