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. 2016 Sep 21;8(8):1612–1619. doi: 10.1080/19420862.2016.1229722

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — Model for the mechanism of action of TAC. As depicted in the model, (1) TAC binds to S. aureus bacteria, (2) TAC bound S. aureus bacteria are internalized by professional phagocytes or other host cells such as epithelial cells. After (3) phagosome-lysosome fusion, (4) lysosomal cathepsins cleave the linker, which (5) releases the active antibiotic dmDNA31 attacking the intracellular bacteria, resulting in (6) elimination of the bacteria.