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Non-compartmental PK parameters of TAC TAb and ac-dmDNA31 following a single IV administration of TAC in mice infected with S. aureus.
| TAC Total Antibody |
Antibody-conjugated dmDNA31 |
|||
|---|---|---|---|---|
| PK Parameters | 25 mg/kg | 50 mg/kg | 25 mg/kg | 50 mg/kg |
| Cmax (nM) | 3850 | 7640 | 5060 | 13100 |
| AUC0-inf (day • nM) | 29560 | 53720 | 12630 | 24390 |
| Clearance (mL/day/kg) | 5.78 | 6.37 | 26.6 | 27.5 |
| Vss (mL/kg) | 115 | 123 | 114 | 110 |
| t1/2λz (day) | 14.0 | 13.8 | 3.81 | 3.73 |
