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. 2016 Sep 9;8(8):1598–1605. doi: 10.1080/19420862.2016.1226716

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — Structure prediction of MEDI3622. (A) Amino acid sequences of MEDI3622 V_H and V_L domains. CDRs are shown in bold and underlined according to Chothia definition.²⁹ (B) Modeled 3-dimensional structure of MEDI3622 variable domains, with V_H in orange and V_L in beige. CDRs are shown in blue. The CDR1L, 2L, 3L, 1H, and 2H of MEDI3622 adopt canonical conformations L1-11A, L2-7A, L3-9A, H1-10A and H2-10B, respectively, and form a relative flat antigen-binding surface with a short CDR3H.