Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Structure alignment of the M-domain structures of TACE and other ADAMs, ADAMTSs and MMPs. Structural alignment of M-domain structures shows that the epitope of MEDI3622, the surface loop of sIVa-sIVb β-hairpin in the TACE M-domain, is a structural feature unique to TACE. The M-domain is shown in magenta for TACE (PDB 3E8R),16 blue for ADAMTS-5 (PDB 3LJT),30 cyan for MMP-9 (PDB 5CUH)31 and gray for ADAM22 (PDB 3G5C).32
