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. 2015 Dec 15;8(6):823–831. doi: 10.1161/CIRCGENETICS.115.001129

Figure 1.

Figure 1.

Distribution of untreated low-density lipoprotein cholesterol (LDL-C) for patients with familial GOF mutations in PCSK9 without LDLR mutations (A) and position of the mutations and the 12 exons of the PCSK9 gene relative to the protein domains (B). †P value indicates reduction for mutation versus overall mean. ‡P value indicates increase for mutation versus overall mean. Dotted line represents mean LDL-C level of all PCSK9 mutation carriers from whom untreated LDL-C levels were available. 1.81 mmol/L=70 mg/dL; 2.59 mmol/L=100 mg/dL.