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. Author manuscript; available in PMC: 2017 Oct 6.
Published in final edited form as: Mol Cell. 2016 Oct 6;64(1):12–23. doi: 10.1016/j.molcel.2016.09.006

Figure 3. General mechanisms of substrate recognition by the APC/C.

Figure 3

Intrinsic factors, encoded in the protein sequence, and extrinsic factors, encoded in the cell state, regulate substrate stability and are likely to determine the timing of substrate degradation.