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. 2016 Nov 1;24(6):572–580. doi: 10.4062/biomolther.2016.183

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Copyright ©2016, The Korean Society of Applied Pharmacology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5. — Effect of 3-DSC on hair growth in C57BL/6 mice. After synchronizing the telogen phase, shaved backs of C57BL/6 mice were topically treated with 3-DSC or ethanol for 15 days. (A) Control, ethanol (50%). (B) 3-DSC (3 mM). Typical photos of dorsal skin (upper panel), histopathological analysis (lower panel). (C) A representative scheme of 3-DSC regulation of WNT/ β-catenin and JAK-STAT pathway in human hair dermal follicle papilla cells. The treatment of 3-DSC not only increased β-catenin and TCF/LEF, a cell growth regulatory transcriptional factor in nucleus, but also interfered with IL-4-JAK3-STAT6 pathway, which activated STAT6 transcription factor.

Fig. 5. — Effect of 3-DSC on hair growth in C57BL/6 mice. After synchronizing the telogen phase, shaved backs of C57BL/6 mice were topically treated with 3-DSC or ethanol for 15 days. (A) Control, ethanol (50%). (B) 3-DSC (3 mM). Typical photos of dorsal skin (upper panel), histopathological analysis (lower panel). (C) A representative scheme of 3-DSC regulation of WNT/ β-catenin and JAK-STAT pathway in human hair dermal follicle papilla cells. The treatment of 3-DSC not only increased β-catenin and TCF/LEF, a cell growth regulatory transcriptional factor in nucleus, but also interfered with IL-4-JAK3-STAT6 pathway, which activated STAT6 transcription factor.