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. 2016 Nov 1;24(6):638–649. doi: 10.4062/biomolther.2016.018

Fig. 11.

Fig. 11.

Effect of DW2007 on the expression of iNOS and COX-2, activation of NF-κB (A), expression of inflammatory cytokines (B), and production of PGE2 and NO (C) in CIA mice. Arthritis was induced by the first intradermal injection of bovine type II collagen and the second intradermal injection of collagen with complete Freund’s adjuvant at the base of the tail of DBA/1 J mice. Test agents (AC, 20 mg/kg DW2007; IB, 50 mg/kg ibuprofen; or CIA, vehicle alone) were orally administrated daily for 20 days from day 1 after the second injection. Proteins were determined in the paw joint tissues by immunoblotting. Cytokines were determined in the paw joint tissues by ELISA (IL-1β, IL-10, IL-17a, TNF-α, and PGE2). NO was measured using Griess reagent. All data indicate mean ± SD (n=7). #p<0.05 vs. control group. *p<0.05 vs. CIA group.