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. 2016 Nov 1;24(6):638–649. doi: 10.4062/biomolther.2016.018

Fig. 7.

Fig. 7.

Effect of AC on the differentiation to Th17 and Treg cells in TLR4−/− mice with DSS-induced colitis. (A) Effect on Th17 cell differentiation. (B) Effect on Treg cell differentiation. DSS, except in the normal control group (NOR), was orally administered to mice treated with saline (DSS) or DW2007 (AC). Test agents (AC10, 10 mg/kg DW2007; AC20, 20 mg/kg DW2007) or saline were orally administered for 3 days after DSS treatment. The mice were killed 18 h after the final administration of test agents. The T cells were isolated from the lamina propria and Th17 and Treg cells were then analyzed by flow cytometry. All values are mean ± SD (n=6). #p<0.05 vs. control group. *p<0.05 vs. DSS group.