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. 2016 Nov 1;24(6):638–649. doi: 10.4062/biomolther.2016.018

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Copyright ©2016, The Korean Society of Applied Pharmacology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 9. — Anti-inflammatory effect of DW2007 in CIA mice. (A) Effect on body weight gain. (B) Effect on arthritis incidence. (C) Effect on macroscopic score (the number and severity of inflamed paws). (D) Effect on paw thickness. (E) Effect on myeloperoxidase (MPO) activity of the paw joint tissues. (F) Effect on histology. Arthritis was induced by the first intradermal injection of bovine type II collagen and the second intradermal injection of collagen with CFA at the base of the tail of DBA/1 J mice except in the normal control group (NOR). Normal control group was treated with saline instead of collagen. Test agents (AC, 20 mg/kg DW2007; IB, 50 mg/kg ibuprofen; or CIA, vehicle alone) were orally administrated daily for 20 days from day 1 after the second injection. All data indicate mean ± SD (n=7). ^#p<0.05 vs. control group. ^*p<0.05 vs. CIA group.