Table 2.

Odds ratio for DSM-IV GAD for serum CRP levels at age 16 years in the ALSPAC cohort.

Groupsa	N	GAD cases, n (%)	Odds ratio (95% confidence interval)
			Unadjusted	Adjusted for age, sex, BMI	Adjusted for age, sex, BMI, social class, ethnicity	Adjusted for age, sex, BMI, social class, ethnicity, maternal education and age at delivery	Additional adjustment for family history of chronic inflammatory conditionsb
Bottom third	1093	3 (0.3)	1.00	1.00	1.00	1.00	1.00
Middle third	1151	9 (0.8)	2.86 (0.77–10.60)	2.92 (0.78–10.92)	2.39 (0.60–9.47)	2.42 (0.60–9.75)	2.25 (0.55–9.20)
Top third	1148	14 (1.2)	4.48 (1.28–15.65)	4.67 (1.28–16.97)	4.69 (1.25–17.51)	4.88 (1.28–18.54)	5.06 (1.31–19.59)
Linear trend	3392	26 (0.76)	1.95 (1.14–3.32)	1.99 (1.14–3.47)	2.11 (1.16–3.85)	2.16 (1.17–3.98)	2.25 (1.19–4.23)

^aThe group at the bottom third of CRP distribution was used as reference category. Cut off values for the top and bottom thirds of CRP distribution in the entire sample were 0.64 and 0.26 mg/L, respectively.

^bIncludes history of arthritis and rheumatism in mother and maternal grandparents.