Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Tobramycin is a potent inhibitor of ataluren-mediated readthrough. The effect of tobramycin on NanoLuc activity in HEK293 cells expressing a UGA (W12X) NanoLuc reporter with either no prior treatment or following treatment with 10 µM ataluren for 48 hours. Initial stimulation of readthrough by ataluren in the absence of tobramycin was 15-fold above background.
