The interactions of avi (yellow) and evn (pink) within their binding sites. H-bonds are colored gray. (A and B) Avi forms H-bonds with A2469, G2470, A2471, U2479, C2480, G2535, and G2536. (C and D) Evn forms H-bonds with G2470, A2471, A2479, C2480, G2535, G2536, and a hydrophilic bond with A2530 phosphate. Both avi and evn bond S54 of rProtein uL16 via hydrophilic interaction.