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. 2016 Oct 19;113(44):E6796–E6805. doi: 10.1073/pnas.1614297113

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Fig. S2. — A-tRNA binding site overlaps with the positions of avi and evn and CTC domain 2 in the D50S–avi and evn structures. (A) A-tRNA (blue) binding site at T70S (teal) crystal structure (PDB ID code 4VD5) superposed on D50S–avi structure (orange/yellow). Avi is shown with surface representation. Clash between A-tRNA and avi shown in black-framed zoom-in. (B) Magnification of A-tRNA elbow and avi interactions with rProtein uL16. Both avi and the A-tRNA interact with R50 and R55 of uL16. The backbone of A-tRNA nucleotides U54 and G53 clash with avi residues A and B. R55 side chain is shifted toward A2469 of H89 upon avi binding. (C) A-tRNA (blue) binding site at T70S (light cyan) crystal structure (PDB ID code 4V6F) superposed on D50S3 avi (orange/yellow) and D50S–evn structures (purple/pink). Avi is shown with surface representation. (D) Magnification of the clash between A-tRNA elbow and CTC second domain.