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. 2016 Oct 17;113(44):12538–12543. doi: 10.1073/pnas.1615051113

Fig. 2.

Fig. 2.

Bidirectional change in arterial pressure by overexpression of prolactin is associated with changes in urinary excretion of nitrite/nitrate and in the expression of 16K prolactin and its downstream genes (*P < 0.05 and **P < 0.01 vs. WT; NS, not significantly different). (A) sBP in WT and prolactin Tg male mice on NC or on the I3C diet determined with a tail-cuff method. (B) Heart rate in WT and prolactin Tg mice fed NC or the I3C diet. (C) Urinary nitrite/nitrate excretion. (D) Food consumption. (E) Renal expression of eNOS in WT and the prolactin Tg mice without and with I3C administration. (F) Immunoblot for Ser1177-phosphorylated and total eNOS in the liver of WT and Tg mice without and with I3C administration. (G) Immunoblot for the full-length (23K) prolactin and 16K prolactin in the plasma of WT and the Tg mice without and with I3C administration. (H) Renal expression of PAI-1 in WT and prolactin Tg mice without and with I3C administration. (I) Renal expression of iNOS in WT and prolactin Tg mice without and with I3C administration.