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A tentative model illustrates how CAS protein regulates the expression of HLA3 and LCIA during the CCM induction by shifting from high-CO2 (HC)-light (A) to low-CO2 (LC)-light (B) conditions. The red structure indicates the CAS protein. The CAS-meditated pathways involved in regulating expression of HLA3 and LCIA are shown as red arrows. The LCIA-mediated pathway involved in regulating expression of HLA3 is indicated as brown arrows. CAH, carbonic anhydrase; PGA, phosphoglyceric acid.
