Appendix Table.
Primary Results across different modeling specifications.
| Vomiting
|
Nausea
|
Total Sympom Score (TSS)
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|---|---|---|---|---|---|---|---|---|---|
| Model 1: Full Model |
Model 2: Pooled trt-effect |
Model 3: Parsimonious Model |
Model 1: Full Model |
Model 2: Pooled trt-effect model |
Model 3: Parsimonious Model |
Model 1: Full Model |
Model 2: Pooled trt-effect model |
Model 3: Parsimonious Model |
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| period 1 | |||||||||
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| slope (daily change) | |||||||||
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| Group A (Stim on) | −0.41 (−0.54,−0.29) p<0.001 | −0.40 (−0.51, −0.29) p<0.001 | −0.40 (−0.51, −0.29) p<0.001 | −0.33 (−0.46, −0.20) p<0.001 | −0.33 (−0.45, −0.22) p<0.001 | −0.33 (−0.45, −0.22) p<0.001 | −1.33 (−1.82, −0.84) p<0.001 | −1.30 (−1.76, −0.85) p<0.001 | −1.30 (01.76, −0.85) p<0.001 |
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| Group B (Stim off) | −0.27 (−0.39, −0.15) p<0.001 | −0.28 (−0.40, −0.17) p<0.001 | −0.28 (−0.40, −0.17) p<0.001 | −0.40 (−0.53, −0.27) p<0.001 | −0.40 (−0.52, −0.28) p<0.001 | −0.40 (−0.51, −0.28) p<0.001 | −1.61 (−2.12, −1.10) p<0.001 | −1.63 (−2.10, −1.16) p<0.001 | −1.63 (−2.10, −1.16) p<0.001 |
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| Trt effect: (Diffs in slopes) | |||||||||
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| A (on) - B (off) ** | −0.14 (−0.31, 0.32) p=0.112 | −0.07 (−0.25, 0.11) p=0.449 | −0.28 (−0.99, 0.43) p=0.441 | ||||||
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| period 2 | |||||||||
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| slope (daily change) | |||||||||
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| Group A (Stim off) | 0.05 (−0.15, 0.24) p=0.632 | 0.08 (−0.08, 0.23) p=0.329 | 0.08 (−0.08, 0.23) p=0.329 | −0.01 (−0.20, 0.19) p=0.948 | −0.02 (−0.18, 0.14) p=0.839 | −0.02 (−0.18, 0.14) p=0.841 | −0.29 (−1.04, 0.50) p=0.494 | −0.21 (−0.83, 0.42) p=0.514 | −0.20 (−0.83, 0.42) p=0.516 |
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| Group B (Stim on) | −0.01 (−0.20, 0.18) p=0.899 | −0.04 (−0.19, 0.11) p=0.607 | −0.04 (−0.19, 0.11) p=0.606 | 0.34 (−0.17, 0.24) p=0.775 | 0.04 (−0.12, 0.21) p=0.583 | 0.04 (−0.12, 0.21) p=0.585 | 0.19 (−0.60, 0.98) p=0.641 | 0.12 (−0.51, 0.75) p=0.701 | 0.12 (−0.51, 0.75) p=0.700 |
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| Trt effect: (Diffs in slopes) | |||||||||
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| B (on) - A (off)** | −0.06 (−0.33, 0.21) p=0.666 | −0.04 (−0.32, 0.24) p=0.775 | −0.46 (−1.56, 0.65) p=0.417 | ||||||
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| Treatment effect difference between periods | |||||||||
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| slope diff Pd2 - slope diff Pd1 | 0.08 (−0.24, 0.40) p=0.616 | 0.03 (−0.31, 0.36) p=0.866 | −0.18 (−1.49, 1.13) p=0.790 | ||||||
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| Pooled trt effect: | −0.12 (−0.26, 0.03) p=0.116 | −0.12 (−0.26, 0.03) p=0.116 | −0.06 (−0.21, 0.09) p=0.428 | −0.06 (−0.21, 0.09) p=0.431 | −0.33 (−0.92, 0.26) p=0.277 | −0.33 (−0.92, 0.27) p=0.277 | |||
1)
Model 1, Full Model: Different Effects of Stimulation by Session, adjusted for age gender ethnicity.
2)
Model 2, Pooled Treatment Effect: Effects of Stimulation are pooled across Sessions, adjusted for age gender ethnicity.
3)
Model 3, Parsimonious Model: Effects of Stimulation are pooled across Sessions, adjusted for age.
4)
Negative values indicate (daily) decreases in Symptoms (Stimulation - No Stimulation).