Table 3.
Mode of interaction | Molecules on cells/tissues |
---|---|
Cross reactivity | |
Surface-expressed proteins | |
Ribosomal P0, P1, and P2 | Glomerular mesangial cells |
α-Actinin | Glomerular mesangial cells |
α-Enolase | Glomerular mesangial cells and epithelial cells |
Annexin A2 | Glomerular mesangial cells and epithelial cells |
Phospholipids | Glomerular mesangial cells and epithelial cells |
Basement membrane | Glomeruli and endothelial cells |
Matrix-expressed proteins | |
Collagen | Glomerular matrix |
Laminin | Glomerular matrix |
Fibronectin | Glomerular matrix |
Fibrin | Glomerular matrix |
Extracellular proteins | |
HSP70 | Intracellular stress protein |
β2GPI | Serum protein |
Charge–charge interactions | |
Heparan sulfate | Glomerular matrix |
Chondroitin sulfate | Glomerular matrix |
Abbreviations: HSP70, human heat shock protien 70; β2GPI, β2-glycoprotien I.