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. 2016 Sep 19;8:81–91. doi: 10.2147/OARRR.S112829

Table 3.

Anti-dsDNA antibodies cross-react with different surface-expressed molecules or directly bind to negatively charged extracellular matrical proteins via electrostatic force

Mode of interaction Molecules on cells/tissues
Cross reactivity
Surface-expressed proteins
 Ribosomal P0, P1, and P2 Glomerular mesangial cells
 α-Actinin Glomerular mesangial cells
 α-Enolase Glomerular mesangial cells and epithelial cells
 Annexin A2 Glomerular mesangial cells and epithelial cells
 Phospholipids Glomerular mesangial cells and epithelial cells
 Basement membrane Glomeruli and endothelial cells
Matrix-expressed proteins
 Collagen Glomerular matrix
 Laminin Glomerular matrix
 Fibronectin Glomerular matrix
 Fibrin Glomerular matrix
Extracellular proteins
 HSP70 Intracellular stress protein
  β2GPI Serum protein
Charge–charge interactions
Heparan sulfate Glomerular matrix
Chondroitin sulfate Glomerular matrix

Abbreviations: HSP70, human heat shock protien 70; β2GPI, β2-glycoprotien I.