Table 6.
The reported sensitivity and specificity of some potential serum and urine biomarkers in lupus nephritis
| Category of specimens | Sensitivity (%) | Specificity (%) |
|---|---|---|
| Serum biomarkers | ||
| Anti-dsDNA IgG (range) | 80.0–88.6 | 92.3–97.7 |
| Anti-nucleosome IgG | 74.7 | 96.0 |
| Anti-histone IgG | 28.2 | 97.7 |
| Anti-Sm IgG | 15.4 | 100 |
| Anti-C1q IgG | 63.0 | 71.0 |
| Anti-C3b IgG | 36.0 | 98.0 |
| Decreased C3c | 64.1 | 88.4 |
| Decreased C4 | 51.3 | 95.3 |
| Urine biomarkers | ||
| NGAL | 79.49 | 80.0 |
| VCAM | 98.2 | 66.7 |
| TGF-β1 | 64.1 | 68.0 |
| MCP-1 | 76.92 | 80.0 |
| IL-17 | 66.67 | 72.0 |
| IL-8 | 34.0 | 55.7 |
| OPG | 74.0 | 78.3 |
| TWEAK | 89.0 | 56.0 |
| miR-29c | 94.0 | 82.0 |