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. 2016 Nov 7;12(11):e1005988. doi: 10.1371/journal.ppat.1005988

Fig 4. Substitutions at residues 375, 377 and 380 confer similar effects on clade B LN40, LN8 and clade C Z1792M Envs.

Fig 4

Neutralization profiles for sCD4 (A), 447-52D (B) and b6 (C) are shown. Each substitution had similar effects on the three different Envs. consistently increasing sensitivity to sCD4. However, only 380P conferred sensitivity to mab b6, while 377V and 380P exposed the V3 loop crown (447-52D epitope), while 375W didn’t. Of note, Z1792M does not carry the 447-52D epitope.