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. 2016 Nov 7;12(11):e1005988. doi: 10.1371/journal.ppat.1005988

Fig 5. Env substitutions in the CD4 binding loop modulate the trimer specific, V2q epitope.

Fig 5

(A) Env substitutions proximal to the Phe-43 cavity, reduced sensitivity to V2q, mabs, PG9 and PGT145, consistent with a more open TAD and trimer. (B) Substitution S365V on the variable, N-terminal flank of the CD4 binding loop enhanced sensitivity to V2q mab PGT145, consistent with a modified (but not more open TAD conformation).