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. 2016 Nov 1;12:2827–2837. doi: 10.2147/NDT.S115116

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© 2016 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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Schematic representation of YNJYD effects on neuroendocrine–immune mechanism.

Note: YNJYD exerts an antianxiety effect on the neuroendocrine–immune system in rats with PSA mainly by decreasing IL-1α levels and downregulating GABA_AR expression in the hippocampus to maintain a balanced neuroendocrine–immune system.

Abbreviations: ACTH, adrenocorticotropic hormone; CORT, cortisol; CRF, corticotrophin releasing factor; FT3, free triiodothyronine; FT4, free thyroxine; GABA_AR, γ-aminobutyric acid type A receptor; IL, interleukin; PSA, poststroke anxiety; TSH, thyroid stimulating hormone; YNJYD, Yi-nao-jie-yu decoction.