Table 2. Summary of myosin heavy chain (MyHC) distribution (fractional content) in EDL and SOL muscles of male and female R6/2 mice and WT controls.
| MyHC | WT ± SEM | n (WT mice) | R6/2 ± SEM | n (R6/2 mice) | Difference (R6/2-WT) | Change (%) | p value | ||
|---|---|---|---|---|---|---|---|---|---|
| Male mice | SOL | IIa | 0.642 ± 0.017 | 12 | 0.518± 0.026 | 10 | -0.125 | -19.40% | 0.001 |
| IIx/d | 0.024 ± 0.024 | 0.049 ± 0.035 | 0.026 | 107.76% | 0.55 | ||||
| IIb | - | - | - | - | - | ||||
| I | 0.334 ± 0.021 | 0.434± 0.023 | 0.099 | 29.77% | 0.005 | ||||
| EDL | IIa | - | 12 | - | 10 | - | - | - | |
| IIx/d | 0.185± 0.017 | 0.297 ± 0.014 | 0.112 | 60.79% | <0.001 | ||||
| IIb | 0.815± 0.017 | 0.703 ± 0.014 | -0.112 | -13.78% | <0.001 | ||||
| I | - | - | - | - | - | ||||
| Female mice | SOL | IIa | 0.512 ± 0.025 | 12 | 0.490± 0.028 | 12 | -0.02 | -4.30% | 0.56 |
| IIx/d | 0.013± 0.013 | 0.014 ± 0.014 | 0.002 | 11.98% | 0.94 | ||||
| IIb | - | - | - | - | - | ||||
| I | 0.475 ± 0.023 | 0.49± 0.034 | 0.021 | 4.32% | 0.62 | ||||
| EDL | IIa | - | 12 | - | 12 | - | - | - | |
| IIx/d | 0.217± 0.015 | 0.362 ± 0.018 | 0.145 | 66.91% | <0.001 | ||||
| IIb | 0.783± 0.015 | 0.638 ± 0.018 | -0.145 | -18.55% | <0.001 | ||||
| I | - | - | - | - | - | ||||
Values presented as mean ± SEM.