Table 3. Summary of myosin light chain (MyLC) distribution (fractional content) in EDL and SOL muscles of male and female R6/2 mice and WT controls.
MyLC | WT ± SEM | n (WT mice) | R6/2 ± SEM | n (R6/2 mice) | Difference (R6/2-WT) | Change (%) | p value | ||
---|---|---|---|---|---|---|---|---|---|
Male mice | SOL | 1s | 0.371 ± 0.009 | 10 | 0.387 ± 0.009 | 12 | 0.016 | 4.17% | 0.25 |
1f | 0.156 ± 0.007 | 0.154 ± 0.013 | -0.002 | -1.22% | 0.90 | ||||
2s | 0.182 ± 0.012 | 0.196 ± 0.014 | 0.014 | 7.60% | 0.46 | ||||
2f | 0.269 ± 0.008 | 0.250 ± 0.006 | -0.019 | -7.14% | 0.07 | ||||
3f | 0.022 ± 0.014 | 0.014 ± 0.004 | -0.008 | -36.72% | 0.14 | ||||
EDL | 1s | - | 10 | - | 10 | - | - | - | |
1f | 0.352 ± 0.007 | 0.404 ± 0.012 | 0.057 | 16.14% | <0.001 | ||||
2s | - | - | - | - | - | ||||
2f | 0.435 ± 0.016 | 0.461 ± 0.003 | 0.020 | 4.51% | 0.24 | ||||
3f | 0.213 ± 0.021 | 0.146 ± 0.012 | -0.008 | -36.20% | 0.003 | ||||
Female mice | SOL | 1s | 0.369 ± 0.010 | 10 | 0.401 ± 0.009 | 12 | 0.031 | 8.36% | 0.03 |
1f | 0.142 ± 0.006 | 0.133 ± 0.008 | -0.029 | -6.45% | 0.36 | ||||
2s | 0.214 ± 0.007 | 0.220 ± 0.010 | 0.005 | 2.25% | 0.70 | ||||
2f | 0.247 ± 0.005 | 0.230 ± 0.009 | -0.017 | -6.77% | 0.13 | ||||
3f | 0.028 ± 0.005 | 0.018 ± 0.004 | -0.010 | -34.90% | 0.16 | ||||
EDL | 1s | - | 10 | - | 12 | - | - | - | |
1f | 0.349 ± 0.003 | 0.413 ± 0.007 | 0.064 | 12.78% | <0.001 | ||||
2s | - | - | - | - | - | ||||
2f | 0.446 ± 0.004 | 0.449 ± 0.005 | 0.003 | 1.59% | 0.67 | ||||
3f | 0.205 ± 0.004 | 0.138 ± 0.007 | -0.067 | -28.62% | <0.001 |
Values presented as mean ± SEM.