. 2016 Nov 7;11(11):e0165523. doi: 10.1371/journal.pone.0165523

Table 2. Genotype, allele frequencies, and HWE of 2SNPs within FTO gene in the present population.

SNP ID	Risk allele/non-risk allele	Genotype			Genotype			Risk allele frequency		HWE		Reported OR	Power (%)	Number of samples for 80% power
SNP ID	Risk allele/non-risk allele	T2D			CONT			T2D	CONT	T2D	CONT
rs1121980	`A/G`	`AA`	`AG`	`GG`	`AA`	`AG`	`GG`	0.233	0.214	0.985	0.486	1.27^a	82	1350
	number of subjects	40	271	443	26	241	419	0.233	0.214	0.985	0.486	1.27^a	82	1350
rs1558902	A/T	AA	AT	TT	AA	AT	TT	0.203	0.180	0.884	0.717	1.27^a	78	1500
	number of subjects	29	249	477	19	208	456	0.203	0.180	0.884	0.717	1.27^a	78	1500

T2D: Type 2 diabetes, CONT; control.

HWE: Hardy-Weinberg Equilibrium.

CaTS power calculator, CaTS: http://www.sph.umich.edu/csg/abecasis/CaTS/).

The prevalence of type 2 diabetes was assumed to be 10%, ∞ = 0.05.

^a OR for T2D of rs9939609 reported by Frayling TM et al. (Science 316: 889–894, 2007)

Since little is known regarding the OR of rs1121980 and rs1558902 for T2D, and both SNPs and rs9939609 were found to be strong LD (r²>0.8) (S2 Table), we used the reported OR of rs9939609^a) for T2D to calculate the estimated power of rs1121980 and rs1558902.