Table 7. Multivariate Cox regression analysis of independent predictors for adverse events.
| Factor | HR | 95% CI | P value |
|---|---|---|---|
| Age (>68 years) | 0.76 | 0.83–1.65 | 0.12 |
| Hypertension | 1.21 | 0.98–3.12 | 0.069 |
| Diabetes mellitus | 1.72 | 1.21–3.96 | 0.017 |
| Smoking | 0.92 | 0.86–1.48 | 0.27 |
| High LDL-C | 1.01 | 0.92–2.45 | 0.089 |
| High TC | 0.87 | 0.74–1.55 | 0.28 |
| CYP2C19 (rs4244285) | 2.01 | 1.46–5.66 | 0.006 |
| CYP3A5 (rs776746) | 1.18 | 0.95–3.43 | 0.097 |
| Interaction of CYP2C19*2 AA with CYP3A5 GG | 2.51 | 2.08–8.72 | <0.001 |
| Clopidogrel resistance | 1.98 | 1.46–5.63 | 0.006 |
HR, hazard ratio; CI, confidence interval; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol.
Note: Input variables include: age, gender, tobacco smoking, hypertension, diabetes mellitus, stroke subtype, body mass index, previous myocardial infarction, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol; triglycerides; hemoglobin A1C; homocysteine, CYP3A4 (rs2242480), CYP2C8*2 (rs17110453), CYP2C8*3 (rs1934980), CYP2C9*2 (rs1799853), CYP2C9*3 (rs1057910), CYP2C19*3 (rs4986893), CYP3A5 (rs776746), CYP2C19*2 (rs4244285), Interaction of CYP2C19*2 AA with CYP3A5 GG and clopidogrel resistance.