Table 3. Correlations of the positive ratios of cells expressing proinflammatory/anti-inflammatory cytokines in carotid plaque with glucose metabolism or proinflammatory/anti-inflammatory properties of circulating monocytes.
Percent of positive cells in plaque |
||||||
---|---|---|---|---|---|---|
TNF-α |
IL-6 |
IL-10 |
||||
ρ | P-value | ρ | P-value | ρ | P-value | |
FPG | 0.191 | 0.371 | 0.346 | 0.098 | −0.471 | 0.020 |
IRI | −0.066 | 0.759 | −0.030 | 0.891 | −0.543 | 0.006 |
HbA1c | 0.246 | 0.247 | 0.466 | 0.022 | −0.428 | 0.037 |
HOMA-IR | −0.014 | 0.947 | 0.087 | 0.686 | −0.640 | <0.001* |
mRNA level in monocytes | ||||||
TNF-α | 0.444 | 0.034 | 0.406 | 0.054 | 0.212 | 0.330 |
IL-6 | 0.309 | 0.142 | 0.148 | 0.491 | −0.130 | 0.544 |
IL-10 | −0.251 | 0.248 | −0.362 | 0.090 | 0.145 | 0.508 |
FPG, fasting plasma glucose; IRI, immunoreactive insulin; HbA1c, hemoglobin A1c; HOMA-IR, homeostasis model assessment of insulin resistance.
P < = 0.0008.
ρ, Spearman's rank correlation coefficient