Table 3.

Biodistribution of ¹¹¹In-liposomal nanoparticles in healthy Sprague Dawley rats

Tissues	Biodistribution of 111In-labeled liposome in rats (%ID/g)
	4%PEG-HS-Chol			4%PEG-HS-CHEM
	2 h	24 h	48 h	2 h	24 h	48 h
Urine	0.264%±0.079%	0.263%±0.072%	0.237%±0.049%	0.215%±0.121%	0.133%±0.010%	0.138%±0.032%
Liver	0.446%±0.028%	0.735%±0.079%	0.633%±0.027%	0.499%±0.080%	0.574%±0.019%	0.422%±0.091%
Femur	0.163%±0.008%	0.213%±0.038%	0.174%±0.037%	0.102%±0.022%	0.112%±0.028%	0.096%±0.014%
Muscle	0.036%±0.011%	0.040%±0.004%	0.038%±0.003%	0.027%±0.006%	0.018%±0.004%	0.015%±0.003%
Spleen	1.747%±0.271%	4.996%±0.508%	4.918%±0.796%	2.602%±0.947%	4.915%±0.432%	4.677%±1.458%
Blood	2.401%±0.161%	0.818%±0.020%	0.275%±0.043%	1.531%±0.281%	0.450%±0.077%	0.132%±0.023%
Brain	0.054%±0.002%	0.024%±0.002%	0.013%±0.003%	0.040%±0.013%	0.013%±0.003%	0.005%±0.000%
Intestine	0.157%±0.014%	0.271%±0.035%	0.244%±0.011%	0.105%±0.034%	0.168%±0.019%	0.142%±0.020%
Kidney	0.312%±0.045%	0.444%±0.065%	0.418%±0.024%	0.188%±0.067%	0.210%±0.016%	0.214%±0.026%
Heart	0.451%±0.057%	0.360%±0.058%	0.367%±0.195%	0.252%±0.022%	0.140%±0.009%	0.112%±0.026%
Lung	0.610%±0.015%	0.452%±0.089%	0.310%±0.049%	0.461%±0.093%	0.187%±0.014%	0.142%±0.009%
Stomach	0.027%±0.006%	0.035%±0.011%	0.049%±0.009%	0.017%±0.002%	0.027%±0.006%	0.037%±0.019%
Thyroid	0.074%±0.009%	0.100%±0.017%	0.089%±0.006%	0.079%±0.049%	0.041%±0.005%	0.040%±0.006%
Testis	0.059%±0.007%	0.078%±0.008%	0.078%±0.013%	0.042%±0.010%	0.036%±0.005%	0.033%±0.001%

Notes: Eighteen animals were injected with ¹¹¹In-4%PEG-HS-Chol or ¹¹¹In-4%PEG-HS-CHEM. Blood samples were taken through tail vein at 2, 24 and 48 h post injections before animals were sacrificed for tissue counting and weighing. Values were expressed as averaged percent injected dose/gram of tissue (%ID/g) (mean ± standard deviation, n=3).

Abbreviations: PEG, polyethylene glycol; HS, hydrogenated soy; Chol, cholesterol; CHEM, cholesteryl hemisuccinate.