Table 4.
Kinetic parameters of 4%PEG-HS-Chol and 4%PEG-HS-CHEM
| Sample ID | Fast (α) component
|
Slow (β) component
|
||
|---|---|---|---|---|
| t1/2 (h) (95% CI) | Fraction (%) | t1/2 (h) (95% CI) | Fraction (%) | |
| 4%PEG-HS-Chol | 0.91 (0.55–2.59) | 43.26±4.84 | 15.26 (10.74–26.39) | 56.74±4.94 |
| 4%PEG-HS-CHEM | 0.55 (0.35–1.23) | 55.23±4.71 | 13.65 (8.34–37.56) | 44.77±4.71 |
Notes: A two-compartment exponential decay model was fitted over the % injected liposome-associated activity to estimate the clearance half-life (t1/2 in hours, with confidence interval) and fraction % of removed liposome content from blood, in both the fast and slow phase.
Abbreviations: PEG, polyethylene glycol; HS, hydrogenated soy; Chol, cholesterol; CHEM, cholesteryl hemisuccinate; CI, confidence interval.