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. 2016 Nov 8;6:234. doi: 10.3389/fonc.2016.00234

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Copyright © 2016 Wu, Park, Deighan, Amaya, Miller, Pan, Zborowski, Lustberg and Chalmers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA ISH test on enzymatic targets. Integrated RNA ISH and ICC staining on enzymatic targets. Integrated RNA ISH and fluorescent ICC staining with customized conjugated CK8, 18, 19-AF488 antibody (ICC), EGFR-type 1 (RNA ISH), and PRMT5-type 6 (RNA ISH). (A) represents the staining of leukocytes spiked with MCF-7 cells at a ratio of 4:1 in cell number. The MCF-7 cells show low positive on PRMT5 and positive on CK and EGFR, while leukocytes are negative on all of them. (B) shows the staining of the NME cells from an esophageal cancer patient blood. PRMT5+ cells are found in this staining.