Table 1.

Animal studies evaluating the effects of cannabidiol (CBD) on social behavior.

Animal model	Treatment regimen and test procedure	Effective dose [/kg]	Reference
Spontaneously hypertensive rats (SHR)	1, 5, 15, 30, or 60 mg/kg CBD, i.p. injection 30 min prior to social interaction test	–	Almeida et al., 2013
MK-801 (acute, 0.3 or 0.6 mg/kg), male Sprague Dawley rats	1 or 3 mg/kg CBD, i.p. injection 20 min prior to MK-801 administration. Social interaction test started 20 min after the last injection	3, 10 (partially)	Gururajan et al., 2011
MK-801 (acute, 0.3 mg/kg), male Sprague Dawley rats	1 or 3 mg/kg CBD, i.p. injection 20 min prior to MK-801 administration. A modified social interaction test started 20 min after the last injection	3	Gururajan et al., 2012
MK-801 (chronic: 1 mg/kg, 28 days), male C57BL/6J mice	30 or 60 mg/kg CBD, i.p. injection 30 min prior to social interaction test	60	Gomes et al., 2015b
MK-801 (acute, 0.08 mg/kg), male Wistar rats	5, 12, or 30 mg/kg CBD, i.p. injection 30 min prior to MK-801 administration. Social interaction/recognition test started 30 min after the last injection	–	Deiana et al., 2015
Male Nrg1 TM HET mice	Chronic treatment with 1, 50, or 100 mg/kg CBD over 3 weeks	50 (partially 1 and 100)	Long et al., 2012
Δ9-THC (1 mg/kg), male Sprague Dawley rats	5 or 20 mg/kg CBD, i.p. injection 20 min prior to Δ9-THC administration. Social interaction test started 20 min after the last injection	20	Malone et al., 2009