Table 3.

Animal studies evaluating the effects of cannabidiol (CBD) on working memory.

Animal model	Treatment regimen and test procedure	Effective dose [mg/kg]	Reference
MK-801 (chronic: 1 mg/kg, 28 days), male C57BL/6J mice	30 or 60 mg/kg CBD, i.p. injection 30 min prior to novel object recognition test	30, 60	Gomes et al., 2015b
Δ9-THC (0.2, 0.5 mg/kg i.m.), male adults rhesus monkeys	0.5 mg/kg CBD, i.m. concurrently with Δ9-THC administration. Visuospatial Paired Associates Learning task and Self-Ordered Spatial Search started 30 min after the injections	0.5 (task selective)	Wright et al., 2013
Δ9-THC-rich and CBD-rich cannabis extracts, male, adult Lister rats	CBD-rich cannabis extracts (0.5, 5, 10, or 50 mg/kg CBD and up to 4 mg/kg Δ9-THC), i.p. 30 min prior to Delayed Matching to Sample task. In addition, CBD-rich cannabis extracts were simultaneously injected with Δ9-THC-rich cannabis extract injection	50 (as it contained nearly 4 mg/kg Δ9-THC	Fadda et al., 2004
MK-801 (0.1 mg/kg, acute), male, adult Lister rats	CBD-rich cannabis extracts (5 or 10 mg/kg CBD), i.p. concurrently with MK-801 injection, 30 min prior to Delayed Matching to Sample task. In addition, CBD-rich cannabis extracts were simultaneously injected with Δ9-THC-rich cannabis extract injection	–	Fadda et al., 2006