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. 2016 Sep 13;65(11):1895–1905. doi: 10.1136/gutjnl-2015-311292

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This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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HOTAIR-mediated carcinogenesis. Hotair acts a guide, (A) redirecting the PRC (EZH2, SUZ12, EED) and H3K27me3 patterns favouring tumour metastasis and (B) silencing of miR-218 that promotes cell proliferation through aberrant activation of Bmi-1. HOTAIR, HOX transcript antisense intergenic RNA; PRC, polycomb repressor complex.