Table 2.

Data and meta-analysis. The ED stands for effective direction and the nagative and possitive each one respectively means protective effect and risk factor.

Gene	Middleton et al. [58]		Beksac et al. [60]		Al Omar et al. [61]		Kim et al. [57]		Meta-analysis
	Cancer N = 90	Control N = 100	Cancer N = 87	Control N = 154	Cancer N = 52	Control N = 70	Cancer N = 241	Control N = 159	P value (ED)
2DL1	86	94	77	147	51	70	241	159	0.32 (−)
2DL2	61	57	68	103	47	55	27	20	0.07 (+)
2DL3	69	85			48	56	240	159	0.99 (+)
2DL4					52	70	241	159	Excluded
2DL5	50	52			45	53	107	59	0.09 (+)
3DL1	83	91			51	66	229	156	0.45 (−)
3DL2					52	70	241	159	Excluded
3DL3					50	70	241	159	Excluded
2DS1	36	39	40	75	43	25	106	56	0.28
2DS2	61	58	54	103	46	50	31	31	0.09 (−)
2DS3	29	34	34	52	40	40	32	29	0.81 (+)
2DS4	82	91			51	70	229	156	0.41 (−)
2DS5	34	26			35	22	80	33	0.0001(+)****
3DS1	34	39	35	76	43	16	99	56	0.18 (+)
2DP1					52	70	241	159	Excluded
3DP1					52	70	241	159	Excluded

^⁎⁎⁎⁎Significance at P < 0.05 level.