Table 4.

Pharmacokinetic parameters of NK105

Dose		Cmax	Tmax	AUC0-inf	t1/2	CLtot	Vss	MRT0-inf
(mg/m2)	n	(μg/mL)	(h)	(μg• h/mL)	(h)	(mL/h/m2)	(mL/m2)	(h)
50	3	14.2	0.69	176	8.84	286	3140	11.0
		± 2.0	± 0.27	± 17	± 3.26	± 27	±160	± 0.6
65	3	18.3	0.71	231	10.3	283	3070	10.8
		± 1.3	± 0.25	± 18	± 2.7	± 22	± 360	± 0.5
80	3	22.0	0.80	302	12.7	284	3080	11.2
		± 3.3	± 0.30	± 104	± 0.8	± 82	± 590	± 2.0
100	6	27.6	0.80	390	12.3	262	3150	12.0
		± 5.3	± 0.30	± 64	± 1.3	± 39	± 580	± 0.9