Table 1.
Comparison of clinical, laboratory and imaging findings between children with febrile urinary tract infection (UTI), non-febrile UTI and asymptomatic bacteriuria (ABU)
| Variable | Group | p | ||||
|---|---|---|---|---|---|---|
| Febrile UTI I n = 13 |
Non-febrile UTI II n = 13 |
ABU III n = 9 |
I vs. II | I vs. III | II vs. III | |
| Age (months); mean ± SD | 8.23 ±3.44 | 6.15 ±2.97 | 3.11 ±1.69 | NS | < 0.01 | < 0.05 |
| Gender, n (%) Boys/girls |
3/10 (23/77) |
8/5 (62/38) |
8/1 89/11) |
< 0.05 | < 0.01 | NS |
| ↑IL-6, n (%) | 11 (85) | 7 (54) | 3 (33) | NS | < 0.01 | NS |
| ↑IL-8, n (%) | 11 (85) | 5 (38) | 2 (22) | < 0.01 | < 0.01 | NS |
| ↑TGF-β1, n (%) | 10 (77) | 5 (38) | 2 (22) | NS | < 0.05 | NS |
| IL-6 (pg/mg)* | 17.78 (6.17; 48.74) |
1.59 (0.00; 4.93) |
0.00 (0.0; 0.91) |
< 0.05 | < 0.01 | NS |
| IL-8 (pg/mg)* | 132.58 (64.41; 1177.97) |
0.00 (0.0; 81.32) |
0.00 (0. 0; 0.0) |
< 0.05 | < 0.01 | NS |
| TGF-β1 (pg/mg)* | 35.51 (2.29; 89.32) |
0.00 (0.0; 67.66) |
0.00 (0.0; 0.0) |
NS | < 0.05 | NS |
| CRP (mg/dl)* | 7.46 (2.67; 20.2) |
0.01 (0.01; 0.01) |
0.01 (0.01; 0.22) |
< 0.001 | < 0.01 | NS |
| ESR (mm/hour)* | 70.00 (53.0; 90.0) |
10.00 (4.0; 20.5) |
7.00 (3.0; 10.0) |
< 0.001 | < 0.001 | NS |
| WBC (mm3); mean ± SD | 19.75 ±4.64 | 15.22 ±4.55 | 12.28 ±228 | < 0.01 | < 0.001 | NS |
| CAKUT, n (%) (±) | 5/8 (38/62) |
3/10 (23/77) |
2/7 (22/78) |
NS | NS | NS |
| DMSA, n = 18 (%) (±) | 7/1 (87.5/12.5) |
5/5 (50/50) |
– | NS | – | – |
↑
– detected in urine
*
median (interquartile ranges); IL-6 – interleukin-6; IL-8 – interleukin 8; TGF-β1 – transforming growth factor β1; CRP – C-reactive protein, ESR – erythrocyte sedimentation rate, WBC – white blood cell count; CAKUT (±) – congenital anomaly of kidney and urinary tract present/absent; DMSA (±) – 99mTc-dimercaptosuccinic acid scan abnormal/normal