Figure 1.

High expression of Metrnl in the gastrointestinal tracts of humans and mice. (A) Immunohistochemical staining of representative human tissues. Strong positive immunostaining in the colon and small intestine, moderate positive immunostaining in the thyroid and kidney, weak positive immunostaining in the liver and adrenal glands, and nearly negative immunostaining in the brain and skeletal muscle were observed. Bar, 50 μm. Staining of Metrnl is indicated by a yellow arrow. (B) Metrnl expression in human intestinal epithelial cells. Bar, 200 μm. (C) Metrnl mRNA expression in 14 tissues from C57BL/6 mice, with the highest expression in the colon, followed by the small intestine and stomach.