Figure 6.
Effects of HupA on the levels of TfR1 and DMT1 and activity of c-aconitase in FAC-exposed rat cortical neurons. FAC (100 μmol/L) incubation caused significant decreases of TfR1 (A) and DMT1 (B) expression, which were significantly reversed by HupA (10 μmol/L) treatment. (C) FAC (100 μmol/L) incubation caused significant increase of c-aconitase activity, which was significantly reversed by HupA (10 μmol/L) treatment. n=5. Data were expressed as percentage of FAC treated group, and shown as mean±SEM. *P<0.05, **P<0.01 vs control group. #P<0.05, ##P<0.01 vs FAC group.