Table 6. Associations of MDR1, TBXA2R, PLA2G7 and PEAR1 polymorphisms with aspirin resistance in ischemic stroke patients.
SNP n (%) | Aspirin insensitive (n=33) | Aspirin sensitive (n=250) | P-value | OR | 95% CI |
---|---|---|---|---|---|
MDR1 (rs1045642) | |||||
TT | 2 (6.1) | 59 (23.6) | 0.021 | 0.421 | 0.233–0.759 |
TC+CC | 31 (93.9) | 191 (76.4) | |||
TBXA2R (rs1131882) | |||||
CC | 27 (81.8) | 156 (62.4) | 0.028 | 2.712 | 1.080–6.810 |
CT+TT | 6 (18.2) | 94 (37.6) | |||
PLA2G7 (rs1051931–rs7756935) | |||||
AA-CC carriers | 3 (9.1) | 3 (1.2) | 0.023 | 8.233 | 1.590–42.638 |
AA-CC noncarriers | 30 (90.9) | 247 (98.8) | |||
PEAR1 (rs12041331–rs1256888) | |||||
AA-GG carriers | 6 (18.2) | 63 (25.2) | 0.378 | 0.660 | 0.260–1.671 |
AG-GG noncarriers | 27 (81.8) | 187 (74.8) |