Table 5.
Treatment | Dose (mg/kg, p.o) |
MPO (mD.O/mg of protein) | SOD (U/mg of tissue) |
GSH (µg/mg of tissue) |
LOOH (mmol/mg of tissue) | |
---|---|---|---|---|---|---|
Non-colitic | Vehicle | — | 1.15 ± 0.50 | 1.36 ± 0.22 | 797.50 ± 111.10 | 2.03 ± 0.58 |
Colitic | Vehicle | — | 4.24 ± 0.71a | 0.15 ± 0.03a | 454.70 ± 78.24a | 3.99 ± 0.60a |
Colitic | 5-ASA | 100 | 3.80 ± 0.24a | 1.10 ± 0.10b | 424.78 ± 59.28a | 4.02 ± 0.29a |
Colitic | HEAS | 10 | 2.96 ± 0.11a,b | 1.35 ± 0.04b | 444.12 ± 18.42a | 3.52 ± 0.42a |
Colitic | HEAS | 100 | 1.26 ± 0.36b | 1.36 ± 0.64b | 482.70 ± 62.52a | 4.14 ± 0.34a |
a P < 0.001 versus non-colitic vehicle group, b P < 0.01 versus colitic vehicle group.