Table 2.
The most common medications causing spontaneous reports of suspected adverse drug reactions received by the MHRA Yellow Card Scheme in children age < 2 years
| Paternal | Transplacental | Transmammary | Neonates | Infant | Vaccinations | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug | Reports | Drug | Reports | Drug | Reports | Drug | Reports | Drug | Reports | Drug | Reports |
| Azathioprine | 1 | Fluoxetine | 21 | Fluoxetine | 4 | Swine Flu Vaccine | 8 | Oseltamivir | 37 | Meningococcal Vaccine | 693 |
| Sulphasalazine | 1 | Citalopram | 20 | Erythromycin | 2 | Caffeine | 5 | Tetracaine | 22 | DTaP/IPV /Hib vaccine | 600 |
| Methotrexate | 1 | Paroxetine | 19 | Sertraline | 2 | Acyclovir | 3 | Amoxycillin | 17 | DTwP/ Hib vaccine | 540 |
| Etanercept | 1 | Venlafaxine | 18 | Citalopram | 2 | Chlorhexidine | 3 | Ibuprofen | 12 | Pneumococcal vaccine | 496 |
| Sertraline | 11 | Lamotrigine | 2 | DTPw HIB vaccine | 3 | Palivizumab | 12 | Bacillus Calmette Guerin Vaccine | 309 | ||
| Olanzapine | 7 | Fluconazole | 2 | Ibuprofen | 3 | Domperidone | 10 | MMR vaccine | 257 | ||
| Valproate | 7 | Desogestrel | 2 | Indomethacin | 3 | Cefotaxime | 9 | Haemophilus influenzae type b vaccine | 190 | ||
| Lamotrigine | 6 | Trimethoprim | 3 | Montelukast | 9 | Poliomyelitis vaccine | 174 | ||||
| Vitamin K substances | 3 | Trimethoprim | 9 | DTwP vaccine | 104 | ||||||
| Ranitidine | 8 | Hib/MEN C conjugate vaccine | 87 | ||||||||
For transmammary, transplacental and paternal all reported medications shown. For neonates, all drugs with n > 2 shown, vaccinations and infants, 10 most commonly reported shown. Vaccinations given to those in neonatal period are shown in both neonates and vaccination columns. DTaP, Diptheria, tetanus and (acellular) Pertussis; DTwP, Diptheria, Tetanus and (whole cell) Pertussis; HIb, Haemophilus influenzae type b; MEN C, Meningococcal group C; MMR, Measles/Mumps/Rubella. Full dataset for all groups in supplementary data section