Table 1.
PD estimates from mean healthy subject data of amlodipine monotherapy
| Amlodipine | |||
|---|---|---|---|
| PD model | Delayed I max | ||
| No. of parameters | 8 | ||
| Parameter | Estimate (RSE%) | Bootstrap estimate | 95% CI |
| SBP BSL (mmHg) | 119(1.03) | 115.32 | 113–118 |
| DBP BSL (mmHg) | 71.3 (2.04) | 65.79 | 63.29–68.9 |
| I max | 0.164 FIX | 0.164 FIX | |
| SBP IC 50 (ng ml −1 ) | 8.27 (32.2) | 10.80 | 0–13 |
| DBP IC 50 (ng ml −1 ) | 2.97 (36.8) | 4.79 | 0–6 |
| SBP Keq (/h) | 0.211 (Teq = 3.3 h) (38.3) | 0.133 | 0.1–0.211 |
| DBP Keq (/h) | 0.821 (Teq = 0.84 h) (104.7) | 0.316 | 0.1–0.821 |
| Residual variability | Estimate (RSE%) | Bootstrap estimate | 95% CI |
|---|---|---|---|
| σ SBP additive (mmHg) | 2.01 (17.4) | 2.92 | 0.91–3.65 |
| σ DBP additive (mmHg) | 1.36 (22.5) | 2.74 | 0.96–3.59 |
BSL, estimated baseline; DBP, diastolic blood pressure; SBP, systolic blood pressure; σ, sqrt(NONMEM SIGMA)