Figure 3. Defining EV and surface-accessible proteome.

(a) Venn diagram of non-treated and PK-treated EVs proteome. The number present in the circle represent the total number of identified proteins in particular data set. (b) Plot of log2 value of relative abundance of proteins from non-treated and PK-treated EVs. Line and dotted line indicate half and 2-fold change, respectively. (c) Among the common proteins, proteins are divided into three groups–2-fold increase, 2-fold decrease, and no change after PK treatment–based on relative protein abundance. (d) Hierarchical diagram of defining EV and surface-accessible proteome.