Table 1. Clinical characteristics of the participating studies.
| Study | Group | n | Age, years | Men, % | HTN, % | BMI, kg/m2 | Diabetes, % | MI, % | CHF, % | |
|---|---|---|---|---|---|---|---|---|---|---|
| Discovery | AFNET/KORA | Cases | 448 | 51.0 ± 7.6 | 68 | 41 | 28.1 ± 5.2 | 8 | 1 | 2 |
| Referents | 438 | 55.8 ± 7.3 | 50 | 45 | 27.7± 4.3 | 4 | 0 | 1 | ||
| AGES | Cases | 399 | 78.6±5.6 | 58 | 90 | 27.2 ± 4.4 | 13 | 6 | 9 | |
| Referents | 2,560 | 76.1±5.4 | 36 | 78 | 27.0 ± 4.5 | 11 | 5 | 1 | ||
| ARIC | Cases | 1,420 | 56.8 ± 5.4 | 57 | 41 | 28.2 ± 5.3 | 13 | 9 | 8 | |
| Referents | 7,633 | 53.8 ± 5.6 | 45 | 24 | 26.8 ± 4.7 | 8 | 3 | 3 | ||
| CCF | Cases | 496 | 58.8 ± 10.7 | 76 | 58 | 30.2 ± 6.2 | 6 | 0 | 8 | |
| Referents | 2,971 | 28.4 ± 22.2 | 38 | – | – | – | – | – | ||
| CHS | Cases | 1,011 | 72.7 ± 5.4 | 44 | 62 | 26.4 ± 4.5 | 14 | 0 | 0 | |
| Referents | 2,190 | 72.0 ± 5.3 | 36 | 52 | 26.2 ± 4.4 | 11 | 0 | 0 | ||
| FHS | Cases | 956 | 71.9 ± 12.3 | 57 | 68 | 28.3 ± 5.5 | 13 | 9 | 3 | |
| Referents | 7,470 | 51.8 ± 15.7 | 44 | 31 | 27.2 ± 5.3 | 5 | 2 | 1 | ||
| HealthABC | Cases | 129 | 74.4 ± 2.9 | 63 | 87 | 26.3 ± 3.9 | – | – | ||
| Referents | 1,532 | 73.7 ± 2.8 | 52 | 62 | 26.6 ± 4.1 | – | – | |||
| LURIC | Cases | 361 | 66.4 ± 27.7 | 72 | 75 | 27.7 ± 4.2 | 45 | 33 | 30 | |
| Referents | 2,598 | 62.2 ± 10.7 | 70 | 73 | 27.4 ± 4.0 | 40 | 44 | 18 | ||
| MGH/MIGEN | Cases | 366 | 53.4 ± 10.5 | 81 | 23 | 27.8 ± 5.0 | 3 | 1 | 3 | |
| Referents | 911 | 47.9 ± 8.8 | 53 | – | – | – | – | – | ||
| PREVEND | Cases | 272 | 61.3 ± 9.4 | 67 | 68 | 27.7 ± 4.4 | 7 | 12 | 3 | |
| Referents | 3,277 | 48.4 ± 12.1 | 50 | 34 | 26.0 ± 4.2 | 4 | 2 | 0.1 | ||
| PROSPER | Cases | 505 | 76.0 ± 3.5 | 58 | 64 | 27.1 ± 4.3 | 11 | 19 | 0 | |
| Referents | 4,739 | 75.3 ± 3.3 | 47 | 62 | 26.8 ± 4.2 | 10 | 13 | 0 | ||
| RS-I | Cases | 954 | 72.6 ± 8.5 | 46 | 65 | 26.7 ± 3.7 | 17 | 11 | 14 | |
| Referents | 4,691 | 68.3 ± 8.8 | 40 | 53 | 26.2 ± 3.6 | 9 | 6 | 7 | ||
| RS-II | Cases | 146 | 71.5 ± 9.7 | 54 | 78 | 27.2 ± 4.3 | 22 | 12 | 6 | |
| Referents | 2,011 | 64.3 ± 7.6 | 45 | 59 | 27.2 ± 4.2 | 12 | 4 | 1 | ||
| SHIP | Cases | 106 | 62.0 ± 10.3 | 63 | 55 | 29.6 ± 5.1 | 23 | 13 | 27 | |
| Referents | 1,815 | 49.0 ± 14.4 | 47 | 24 | 27.2 ± 4.5 | 11 | 3 | 9 | ||
| WGHS | Cases | 959 | 58.2 ± 7.6 | — | 40 | 27.2 ± 5.3 | 5 | — | — | |
| Referents | 19,897 | 53.9 ± 4.9 | — | 23 | 25.8 ± 4.9 | 2 | — | — | ||
| Replication | UK Biobank | Cases | 2,363 | 62.3 ± 5.8 | 70 | 52 | 29.1 ± 5.5 | 13 | 13 | 12 |
| Referents | 114,746 | 56.7 ± 7.9 | 47 | 21 | 27.5 ± 4.8 | 5 | 2 | 0 |
HTN – hypertension, defined as systolic blood pressure ≥140 mmHg, or diastolic blood pressure ≥90 mmHg, or antihypertensive treatment. BMI – body mass index; Diabetes – diabetes mellitus; MI – myocardial infarction; CHF – heart failure. “−” Signifies data not available.